I keep it simple. I set up a basic carolina rig type set up. Egg sinker above a bead...tied to barrel swivel...then a leader to the hook. I try to keep the line vertical in the water when drifting...so sinker weight is kind of dependent on how fast I am drifting.
I set rods in rod holders so I use circle hooks. I use cut gizzard shad for bait. Depths vary based on what I'm seeing on the depth finder...but I'm often just a few feet up off the bottom. A lot of time I'll just drop the line until the sinker hits bottom then reel anywhere from 1 - 3 turns of the reel handle.
I also use my I-pilot to control drifts most the time...some times I'll spot lock an area and hold if I like what I'm seeing on the electronics. Drift socks can also be a big help to control your drift.