Kind of depends on where you plan to fish and what species you are targeting. The Pack boys up at Packs are good for about anything on the upper end. Then Blacks Fish Camp has good guides. Some specialize in catfish and/or stipers.
Also several guides on the canal, but I am not familar with that end of the lake so some of the other guys will have to help out.
You might want to do a search on here for Santee Cooper fishing guides. Several folks in the past have posted trips with guides and how they liked the guide.
SeaRay
Mark 1:17 ...I will make you fishers of men