Sparty ..... check this out --> Cave Run Lake Fish Attractors - Google My Maps
The habitat icon pictures are explained in the left margin, as to what type of habitat cover is placed there. Click on one of those icons & the GPS coord's (3 versions) appear in the left margin.
I've always used the Alfrey Ramp, for the most part, but have launched at the Scott's Creek Marina ramp.
It's a pretty straight forward 1.5hr drive from Lex. -- East on I64 to 801 which runs along the North side of the lake. The Alfrey Ramp is just down 801 from the Scott's Creek Marina. You turn onto the Twin Knobs Campground road, then take the road to the left to the Alfrey Ramp. The Twin Knobs Campground ramp is for the campers. There is a launch/parking fee of $5.00, and there should be a station near the bathrooms in the parking lot where you can get an envelope/tag.
IMHO ... if it's April/May, you're talking pre-spawn to spawn period, so I'd look at offshore cover that's near the mouths of creeks on the North banks and work my way back into those creeks.
If it's Sept/Oct ... I won't be of much help, as I've not fished the lake during that period enough to offer any suggestions.
I also suggest you contact LittleJohn for more comprehensive info/help.