once a year in the spring
I change mine once a year in the spring. Usually at the beginning of March. I need to get new o rings because the last time I changed it, the o rings looked a bit cracked. I'll get on mercury marines website and see how to order some new ones.
Lower unit oil in the two strokes is the most important thing to change. It's like the oil in your car. You gotta change it or it will break down and your gears will wear out prematurely. Lower unit work is expensive. An ounce of prevention is worth more than a pound of cure in this case.